The objective of this work was to develop piroxicam non aqueous emulsion and to understand the kinetics of drug release by applying mathematical and model-dependent approaches. Four formulations of non aqueous emulsions were prepared by the hand mixing method using PEG 200 and PEG 400 polar phases and olive oil, Liquid paraffin and MCT as a non polar phases. The in vitro drug release was studied in pH 7.2 Phosphate buffer using Franz diffusion cell. Zero-order, first-order, Higuchi, Hixson-Crowell, and Korsmeyer et al. models were used to estimate the kinetics of drug release. The criteria for selecting the most appropriate model were based on the goodness-of-fit test. Furthermore, experimentally, we assessed the in vitro transfer of the prepared piroxicam non aqueous emulsion for steady state flux and permeability coefficient through an artificial cellulose acetate membrane.
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